Liver Cells May Die More Quickly in HIV/HCV Coinfection (DDW, May 2000)
OF HEPATITIS C VIRUS AND HIV-1 ON HEPATIC PARENCHYMAL AND MONONUCLEAR CELL
PROLIFERATION AND APOPTOSIS.
Andrew H. Talal, Herman Yee, Douglas T. Dieterich, Weill Med Coll of Cornell Univ, New York, NY; New York Univ Med Ctr, New York, NY.
Comparing virus infected to seronegative individuals, the
mean CD3+ T cell number was significantly increased (32.4 vs. 15.9, p <
0.05). The mean number of CD4+ (2.8 vs. 4.5) and CD8+ (16.2 vs. 10.1) T cells
did not differ significantly between the two groups. Comparing HCV/HIV-1
co-infected and HCV mono-infected individuals, the mean number of CD8+ (19.6 vs.
12.8, p < 0.05) T cells was significantly increased while the number of CD4+
T cells did not differ significantly between the two groups. Comparing
virus-infected to seronegative individuals, the mean number of proliferating
(3.4 vs. 0.4, p < 0.05) and apoptotic (0.8 vs. 0.0, p < 0.001) cells was
also increased. Comparing HCV/HIV-1 co-infected and HCV mono-infected
individuals, the number of proliferating and apoptotic cells were greater but
did not differ significantly. Viral infection with HCV increases hepatic cell
turnover when compared to seronegative individuals.
Talal concluded dual infection with HCV and HIV-1 further increases hepatic cellular turnover and may partially explain the accelerated course of liver disease in the HCV/HIV-1 co-infected individuals.
Cellular changes in uninfected, HCV mono-infected,
and HCV/HIV-1 co-infected subjects:
|Normal||15.9 ± 5.9||4.5 ± 7.7||10.1 ± 3.2||0.4 ± 0.4||0.0|
|HCV||31.8 ± 16.0||3.2 ± 3.2||12.8 ± 6.3||2.9 ± 2.4||0.7 ± 0.5|
|HCV/HIV-1||32.5 ± 6.8||2.5 ± 0.7||19.6 ± 4.0||3.9 ± 2.1||0.9 ± 0.3|