icon-folder.gif   Conference Reports for NATAP  
  37th Annual Meeting of the European Association for the Study of the Liver
Madrid, Spain, April, 2002
Back grey_arrow_rt.gif
  This study was presented at the EASL liver meeting in Madrid by a Greek research group from the University of Crete. The aim of this study was to define the natural history of compensated cirrhosis and analyze age, sex and cirrhosis etiology at diagnosis to identify prognostic factors available at diagnosis which might influence the time or decompensation or survival.
The authors retrospectively analyzed data of 306 compensated cirrhotic patients from diagnosis to decompensation and, death, using the log rank test and univariate Cox PH models.
RESULTS: 54.9% of the patients were males, 47.06% were <64 years old. 56 had alcoholic cirrhosis, 17 had alcoholic cirrhosis with a viral infection, 45 had HBV cirrhosis, 145 had HCV cirrhosis and 43 had cryptogenic cirrhosis. 150 patients (49.02%) became decompensated within the study period. Median time to decompensation was 58 months (95% CI 51 and 65 months). Patients with HCV cirrhosis had longer times to decompensation than the other groups (81 months).
65% of all patients remain compensated 3 years after diagnosis, reduced to 34% after 7 years. 70 patients (22.88%) died within the study period. The median survival time was 126 months (95% CI 103 to 149 months). The prognostic factors available at diagnosis that were found to have a significant effect on decompensation and survival time were sex (p = 0.0024 and p = 0.0007) and etiology of cirrhosis (p < 0.0001 and p = 0.0024). The authors found that females with HCV cirrhosis have the longest time until decompensation and the longest survival times.