icon-folder.gif   Conference Reports for NATAP  
  9th European AIDS Conference (EACS)
Warsaw, Poland
Oct 25-29, 2003
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Assisted Medical Procreation for HIV+ and HCV+ Couples & Pregnancy
  Reported by Jules Levin
This abstract was reported at the European AIDS Conference in Warsaw October 2003. Since May 2001, AMP in HIV or HCV infection is allowed in France. To respond to the increasing number of serodifferent couples wishing to have children with a lesser risk, a multidisciplinary management clinic was set up. In addition to AMP procedures, each specialist perform a specific evaluation before collaborative decisions. For HIV-1 or HCV infected men, HIV-RNA and DNA highly sensitive tests (5 copies) or HCV-RNA PCR were performed on semen samples, the goal being to obtain spermatozol final fraction (ff) isolated by density gradient, free of viruses. They recommend ART for patients with plasma HIV >10,000 copies/ml.
Between Nay 2002 and May 2003, 110 couples did seek information and 85 started AMP: 24 HIV-infected women, 54 serodifferent couples with a man HIV and/or HCV and 7 with both man and woman infected.
The median age range for women was 36 (26-45) yrs. 70 samplesfrom 38 patients, 21/38 HIV, 13/38 HIV+HCV and 4 HCV infected were analyzed. The ff was positive for HIV-RNA and DNA in 5 of 5 patients, respectively. All but one patient had undetectable blood HIV-RNA. HCV-RNA was positive in 6/17 patients in seminal plasma but in only one for the ff. 18 couples started Intrauterine insemination with 9 pregnancies for 44 cycles and 8 performed in vitro fertilization or intracytoplasmic Sperm Injection (ICSI) with 2 pregnancies. The first baby is expected in August 2003.
Reference: 9th European AIDS Conference, October 2003, Warsaw, Poland. Abstract F3/3. Multidisciplimary Management of HIV and/or HCV Infected Couples Wishing to Have Children With Lesser Risk of Viral Transmission: Assisted Medical Procreation (AMP) for HIV-1 or HCV Serodifferent Couples
MD Roland TUBIANA, Infectious Diseases Dept Pitie Salpetriere Hopital, bd de l’hopital, 750013 Paris, france. Phone: 0033-142160171.