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Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections
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Journal of Viral Hepatitis
Volume 11 Issue 5, September 2004
C. HÈzode1,2, F. Roudot-Thoraval2,3, E.-S. Zafrani4, D. Dhumeaux1,2 and J.-M. Pawlotsky2
Departments of 1Hepatology and Gastroenterology, 2Virology (EA 3489) , 3Public Health, and 4Pathology, HÙpital Henri Mondor, UniversitÈ Paris XII, CrÈteil, France
Summary
This study reports evidence that hepatocellular steatosis, a frequent histological feature of chronic hepatitis C, is principally metabolic in hepatitis C virus (HCV) genotype 1-infected patients, whereas it is principally virus-induced in HCV genotype 3-infected patients.
Multivariate analysis of data on 176 patients with chronic hepatitis C revealed that the severity of steatosis was independently related to HCV RNA load alone in patients infected by HCV genotype 3, whereas it was independently related to the body mass index, daily alcohol intake and histological activity grade (but not viral load) in patients infected by HCV genotype 1.
These findings suggest that steatosis is a cytopathic lesion induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se or at the usual in vivo expression levels.
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