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Oral Cancer In Men Associated With HPV
  Oral Cancer In Men Associated With HPV
Feb 2, 2009 ... Of an estimated 28900 cases of oral cancer a year, 18550 are in men. ''The high risk of HPV-associated cancers in men suggests that ...
38 percent of oral squamous-cell cancers are HPV related. .....'Patients who have HPV infections are at higher risk for these cancers,'......HPV can enter the mouth during oral sex. researchers are finding that many oral cancers in men are also associated with the virus. 40 percent of the tumors in men were infected with HPV. the vaccine that was approved largely for women and for cervical cancer could have broader implications, and also for other cancers that occur in both men and women....People with tumors with high HPV levels were significantly more likely to respond to treatment. They were also more likely to survive their cancer and to survive over all.....Now medical companies are marketing several new screening tests and devices to dentists, saying they will vastly improve early detection of oral cancer. The devices, which can cost several thousand dollars, use rinses, dyes and different types of lights to detect abnormal cells.....some insurers have started covering it....In small studies, the devices successfully detected potentially malignant lesions that experienced specialists missed with the naked eye....Yet oral cancers associated with the papillomavirus are still rare, and they typically occur near the base of the tonsils and the back of the tongue, where they are very difficult to see at the earliest stages, even with the use of these devices, said Dr. Maura L. Gillison, a professor of medicine at Ohio State who is a leading expert on oral HPV. But Dr. Epstein says the devices may help. "If you're someone with a high risk of HPV exposure, meaning that you've had oral sex with multiple partners, you need to be examined carefully," he said. "Higher-risk people could maybe benefit from some of these adjuncts."....Researchers are working on the holy grail of oral cancer screening: a test that can analyze saliva for early gene changes that could lead to the disease.
"Oral sex can cause throat cancer"
Oral-Genital Sex & Throat Cancer
May 9, 2007 ... The results prove the connection between HPV and oral cancer beyond any reasonable doubt, Viscidi says. "This is a major study in terms of ...
The new findings should encourage people to consistently use condoms during oral sex as this could protect against HPV, the team says. Other experts say that the results provide more reason for men to receive the new HPV vaccine.. People who have had more than five oral-sex partners in their lifetime are 250% more likely to have throat cancer than those who do not have oral sex, a new study suggests. Oral-genital contact was strongly associated with oropharyngeal cancer, but we cannot rule out transmission through direct mouth-to-mouth contact or other means." A second study found this risk of oral-HPV cancers is small.
Merck Vaccine Effective in Men
In Young Men, HPV Vaccine Prevents Conditions That Lead to Cancer
there is increasing recognition that HPV is likely to play a role in some oropharyngeal cancers, which disproportionately affect men. These cancers develop later in life. The extent of the role of HPV in oral cancers is controversial. "The evidence shows that the association between HPV and oropharyngeal cancer is strong," says UCSF oral surgeon and cancer researcher Brian Schmidt, DDS, MD, PhD.
Cancer biology: HPV's unexpected effect
Nature 460, 668 (6 August 2009)
People infected with human papillomavirus (HPV) have a better chance of surviving a type of head and neck cancer than those without the infection. The findings may help explain why black cancer patients fare worse than whites.
Kevin Cullen of the University of Maryland in Baltimore and his colleagues found that whites with squamous cell carcinoma of the throat survived about three times longer than blacks with this condition. By analysing biopsy specimens from 196 whites and 28 blacks, the authors determined that this disparity might be explained by HPV status: the survival rate was two-and-a-half times higher for infected patients than uninfected patients, and white patients were almost nine times more likely to be HPV-positive than blacks.
Cullen says HPV may make tumours more vulnerable to chemotherapy and radiation.
"The great success of HPV vaccines in reducing cervical cancer risk is a model for chemoprevention studies in HPV-related oropharyngeal carcinogenesis (17). These studies would benefit from an understanding of oropharyngeal premalignancy, which has yet to be characterized in the literature. Nevertheless, infection clearly precedes cancer development-seropositivity to HPV-16 confers a 14-fold increase in subsequent risk of oropharyngeal cancer (28). Although HPV DNA has been detected in in situ, invasive, and metastatic disease (29), the histopathologic progression from infection to in situ disease is poorly documented. It likely involves HPV infection of the basal cell layer of tonsillar crypts, which seem to be uniquely prone to transformation by the virus (30).
"Significant data of the last few years show that human papillomavirus (HPV; primarily HPV-16) infection is associated with a significant percentage of oropharyngeal cancers, primarily of the base of the tongue and tonsil (12, 13). Furthermore, the incidence of oropharyngeal cancer is increasing, as is the prevalence of HPV infection in oropharyngeal cancer patients (14, 15). Very recent data indicate that HPV-positive cancers have a significantly better prognosis than do the HPV-negative diseases (16). The striking effect of HPV on cervical screening (17) and neoplasia risk and the U.S. Food and Drug Administration approval of HPV vaccines to reduce this risk (18) highlight the growing focus on HPV in research of head and neck cancer etiology, therapy, and prevention."
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