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NIH Announces Funding & Grant Application Requests For Cure Research
Title: Martin Delaney Collaboratory: Towards an HIV-1 Cure (U19)
Release Date: June 25, 2010
Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH), National Institutes of Health (NIH), encourage grant applications from institutions/organizations to address the problem of HIV-1 persistence in HIV-1-infected persons treated with suppressive antiretroviral drug regimens. This FOA will support research in four areas: (1) basic research to identify and characterize the cellular reservoirs of HIV-1 in treated individuals, (2) development of assays that are physiologically relevant and that comprise a spectrum of cell types that may harbor latent HIV-1 or permit viral replication in the presence of effective antiretroviral drug regimens, (3) screening of drug candidates that target latent/persistent HIV-1, and (4) development and initial testing of new agents or strategies aimed at the eradication of HIV-1. The goal of this initiative is to expand the knowledge base on HIV-1 latency and persistence so that eradication strategies can be designed, developed and evaluated. The application must include basic research and translational activities as essential components, and collaborators must include a private sector entity.
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