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Dual Oral Combination Therapy with the NS5A Inhibitor Daclatasvir(DCV; BMS-790052) and the NS3 Protease Inhibitor Asunaprevir(ASV; BMS-650032) Achieved 90% Sustained Virologic Response (SVR12) in Japanese HCV Genotype 1b-Infected Null Responders
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Reported by Jules Levin
AASLD No 5-9 2011 SF
K Chayama,S Takahashi, Y Kawakami, K Ikeda, F Suzuki, J Toyota,Y Karino,T Ohmura, H Ishikawa, H Watanabe, T Guo,F McPhee, EA Hughes, H Kumada
Dual oral therapy with daclatasvirand asunaprevirprovided rapid and persistent viral suppression in null responders with genotype 1b infection
- All patients who completed 24 weeks' treatment achieved SVR24
- HCV RNA also undetectable 24 weeks post-treatment in patient who discontinued after only 2 weeks
No apparent association between baseline resistance polymorphisms and virologic outcome
Daclatasvir+ asunaprevircombination was generally well tolerated
- Adverse event profile compares favorably with historical experience withpeg-alfa/RBV
High cure rates are possible with dual oral DAA therapy in patients with genotype 1b infection
peg-alfa/RBV, peginterferon alfa + ribavirin; SVR, sustained virologic response.
1. PoynardT, et al. Gastroenterology 2009;136:1618-1628;
2. Jensen DM, et al. Ann Intern Med 2009;150:528-540;
3. Zeuzem S, et al. N Engl J Med 2011;364:2417-2428;
4. Bacon BR, et al. N Engl J Med 2011;364:1207-1217;
5. GaoM, et al. Nature2010;465:96-100;
6. McPhee F, et al. J Hepatol2010;52(suppl1):S296;
7. BronowickiJP, et al. J Hepatol 2011;54(suppl1):S472;
8. Lok A, et al. J Hepatol 2011;54(suppl1):S536.
ClinicalTrials.gov identifier NCT01051414.
cEVR, complete early virologic response; EOTR, end of treatment response; eRVR, extended rapid virologic response; IFN, interferon; RVR, rapid virologic response.
1. Bronowicki JP, et al. J Hepatol 2011;54(suppl 1):S472.
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