icon-    folder.gif   Conference Reports for NATAP  
  18th CROI
Conference on Retroviruses
and Opportunistic Infections
Boston, MA
February 27 - March 2, 2011
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Low CD4 Count on Effective HAART is Associated With Immunologic and Vascular Dysfunction
  Reported by Jules Levin
CROI 2011 March 2 Boston
Hiroyu Hatano1, Priscilla Hsue1, Peter Hunt1, Jeffrey N. Martin1, Tzong-Hae Lee2, Elizabeth Sinclair1, Michael P. Busch1,2, and Steven G. Deeks1 1University of California, San Francisco; 2Blood Systems Research Institute, San Francisco, CA



Emerging data from a number of independent cohorts indicate that the current CD4+ T cell count on suppressive HAART is a strong predictor of subsequent non-AIDS morbidity and mortality. This effect has been most consistently seen among treated individuals with a CD4+ T cell count <350 cells/mm3. We therefore undertook a comprehensive immunologic and virologic assessment of treated patients who had undetectable viral loads and either a "low" (<350 cells/mm3) or a "high" (≥350 cells/mm3) current CD4+ T cell count.