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2 Studies reporting increased heart disease risk in HIV+ using Framingham Score & Imaging/Markers (Glasgow 2012)
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Reported by Jules Levin
Glasgow 2012 Nov 11-15
from Jules: Two studies reported at Glasgow last month on the increased risk HIV+ individuals face for heart disease. Many studies have reported that HIV+ individuals face a risk for developing heart disease at an earlier age and an increased risk for developing heart disease overall. The first study immediately below use the Framingham Risk Score equation & studied "real age" compared to "actual heart age" and found as you can see in the table below heart age was greater in HIV+s for non-smokers and much greater for smokers. So this study reports for example, an HIV+ male in the age group 50-59 their real mean age was 53 but their "heart age" was 60. Similarly for women non-smokers in the 50-59 age group their mean real age was 55 & their heart age was 63. Of note for women over 60 yrs of age the mean real age was 66 & their heart age was 82.
The 2nd study, see attached report, gave patients imaging tests: epi-aortic vessels ultrasonography, brachial atery flow mediated dilation (FMD), and checked markers as well: endothelial cytokine inflammatory markers, and also standard risk factors for heart disease: lipis, glucose, BMI. This study PREVALEAT 2 (PREmature VAscular LEsions and Antiretroviral Therapy II) is an ongoing multicenter, longitudinal cohort study aimed to evaluate cardiovascular risk in a group of patients starting their first HAART. It includes all consecutive naive patients with less than 200 CD4s who may start PI/r-based or NNRTI-based + 2 NNRTIs regimen of therapy. This poster report did not sort out responses by which actual HAART regimen a patient was taking. The authors concluded these patients "show a relevant deterioration of CV conditions in terms of ultrasonographic data, flow mediated dilation and cytokine markers."
Too old too soon? Heart age compared with actual age in HIV positive individuals
T-L Davies1, M Gompels2 and M T May1 1School of Social and Community Medicine, University of Bristol. 2North Bristol NHS Trust, HIV Service, Bristol, UK
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