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Immunologic predictors/Inflammation of coronary artery calcium progression in a contemporary HIV cohort
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AIDS Feb 2014
Baker, Jason V.; Hullsiek, Katherine Huppler; Singh, Amrit; Wilson, Eleanor; Henry, Keith; Lichtenstein, Ken; Onen, Nur; Kojic, Erna; Patel, Pragna; Brooks, John T.; Hodis, Howard N.; Budoff, Matt; Sereti, Irini; for the CDC SUN Study Investigators
Identifying immunologic mechanisms that contribute to premature cardiovascular disease (CVD) among HIV-positive patients will inform prevention strategies.
Methods: Coronary artery calcium (CAC) progression was studied in an HIV cohort. Immunophenotypes were measured on baseline cryopreserved peripheral blood mononuclear cells using multicolor flow cytometry. Logistic regression identified predictors of CAC progression after adjusting for traditional and HIV-related risk factors.
Results: Baseline characteristics for the analysis cohort (n = 436) were median age 42 years, median CD4+ cell count 481 cells/[mu]l, and 78% receiving antiretroviral therapy. Higher frequencies of CD16+ monocytes were associated with greater likelihood of CAC progression, after adjusting for traditional and HIV risk factors [odds ratio per doubling was 1.66 for CD14+/CD16+ (P = 0.02), 1.36 for CD14dim/CD16+ (P = 0.06), and 1.69 for CD14var/CD16+ (P = 0.01)]. Associations for CD16+ monocytes persisted when restricted to participants with viral suppression. We found no significant associations for CAC progression with other cellular phenotypes, including T-cell activation and senescence markers.
Conclusion: Circulating CD16+ monocytes, potentially reflecting a more pro-atherogenic subpopulation, independently predicted greater CAC progression among HIV-infected persons at low risk for AIDS. In contrast to T-cell abnormalities classically associated with AIDS-related disease progression, these data highlight the potential role of monocyte activation in HIV-related CVD risk.
Intermediate and nonclassical monocyte phenotypes may reflect a more activated immunologic state, demonstrating greater release of pro-inflammatory cytokines and an affinity for attaching to vascular surfaces,
respectively [20-23]. These data, along with the well accepted role of monocytes in CVD pathogenesis [24], motivated our decision to study monocytes subpopulations along with more traditional T-cell phenotypes associated with HIV disease risk.
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