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Inflammatory Biomarkers Decline but Do Not Normalize after 10 Years of cART
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Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
KA Lichtenstein1, R Alam1, C Armon2, V Knight1, L Shapiro3, G Pott3, P Merkel1 1Department of Medicine, National Jewish Health, Denver, CO; 2Department of Epidemiology, Children's Hospital Colorado, Aurora, CO; 3Veterans Administration Medical Center, Denver, CO
Program abstract-
Background: HIV infection is characterized by a state of chronic inflammation (CI). The degree to which combination antiretroviral therapy (cART) contributes to or ameliorates CI over time is unclear.
Methods: We measured levels of several inflammatory biomarkers (IB) in the 10 year period following initiation of cART in 327 patients participating in the Study to Understand the Natural History of HIV Infection in the Era of HAART (SUN Study) who had HIV-RNA levels
Results: Over the 10 years following initiation of ART, IB levels in the cART-E group were significantly higher vs. those of HNCs (p
Conclusions: After 10 years of cART, levels of IBs decline but remain elevated vs. HNCs. There were no significant differences in levels seen with PI vs. NNRTI based cART.
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