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HIV-Infected Persons with Type 2 Diabetes have
Evidence of Endothelial Dysfunction
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Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
Malene Hove1, Julie Christine Gaardbo1, Hedda Hoel2, Lilian Kolte3, Ingebjorg Seljeflot2, Allan Vaag1, Jan Gerstoft1, Henrik Ullum1, Marius Troseid2, Susanne Dam Nielsen1. 1Rigshospitalet, Copenhagen University Hospital, Denmark, 2Oslo University Hospital, Ulleval, Norway, 3Hvidovre Hospital, Copenhagen University Hospital, Denmark
fro Jules: they must mean additive not addictive in Conclusion
program abstract
Background: Increased incidence of cardiovascular diseases (CVD) in HIV-infected persons compared to the general population has been described. Likewise, Type 2 diabetes (T2D) is an independent risk factor for CVD. T2D is characterized by endothelial dysfunction. Endothelial dysfunction has been suggested as possible cause to increased risk of CVD in HIV infection. Little is known about the combined effect of HIV infection and T2D on endothelial function. We hypothesized an additive effect of HIV infection and T2D on endothelial dysfunction.
Methods: A cross-sectional study was performed including 50 HIV-infected persons on cART and with HIV RNA t test. Data are given as mean (95%CI).
Results: HIV+T2D+ had elevated ADMA (0.67 μM (0.63-0.72) compared to HIV+T2D- (0.60 μM (0.57 - 0.64) p=0.017), HIV-T2D+ (0.57 μM (0.51-63) p=0.008) and HIV-T2D- (0.55 μM (0.52- 0.58) p
Conclusions: Evidence of endothelial dysfunction was found in HIV-infected persons with T2D compared to HIV-infected persons without T2D. Thus, Our data indicate an addictive (additive) effect of HIV infection and T2D on endothelial dysfunction possibly leading to elevated risk of CVD. This underlines the clinical importance of effective CVD prevention strategies in this group of patients.
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