You should not be concerned if the doses of these drugs are low. All drugs
that are metabolized by the liver can have alterations in clearance from the
body, if there is significant liver damage. We use up to 6 ,500mg tablets of
acetaminophen without any problem as well as non steroidal
antinflamatories. You are using codeine in very low doses, and again this
should not be a problem, unless significant liver disease is present.