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Statistically, is the HCV likely to progress?
Dear Dr. Chung,
In 1978 I contracted HCV in New York via a transfusion. I'm 52 years old with only slightly elevated ALT at 64.
I've had 3 biopsies: the first in 1997 showed stage 1 fibrosis; the second in 1999 after combination interferon and Ribaviron treatment in a Stanford study with 800 mg of Ribaviron (I'm 200 #s) showed only inflamation; and The third, after a second unsuccessful Ribaviron Interferon treatment for 10 months in 2001 showed stage 3 fibrosis During the first Stanford study I went into remission with no HCV detectable by PCR. At the end I relapsed In the second treatment, HCV RNA never disappeared completely. Should I take Pegasys and Ribaviron? How much? Statistically, is the HCV likely to progress
  Dr Chung Writes-  
You are defining a steady progression of liver disease. i would therefore treat with PEG interferon + ribavirin at currently approved doses.
from Jules Levin: relapsers to previous HCV therapy tend to respond better to pegylated interferon+RBV.
  Dr. Chung      
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