Have you had any experience with the use of serum hyaluronic acid (HA)
levels to monitor the progression of chronic liver disease? This serological
test is commonly used in Japan in place of liver biopsy to distinguish
between fibrosis and cirrhosis in patients with HCV and alcoholic liver
disease. While this test may not replace liver biopsy in the US, do you
think it could provide valuable information reflecting the histopathological
changes occurring in the liver between biopsies, and possibly reduce the
frequency of liver biopsy?