Back grey_arrow_rt.gif
Women with HIV can benefit from testosterone treatment
  NEW YORK (Reuters Health) - Treatment with transdermal testosterone is well tolerated and can markedly increase muscle strength in HIV-infected women with low body weight, according to a report published in the April 26th issue of the Archives of Internal Medicine.
"There has been very little research in the use of androgens to treat HIV-infected women," senior author Dr. Steven Grinspoon, from the Massachusetts General Hospital in Boston, said in a statement. "We found that giving natural testosterone at levels that are normal for women produces significant improvement for patients with few other treatment options."
The study involved 57 women who had lost an average of 18% of their pre-illness weight (mean BMI, 20.6) and had total testosterone levels below the median of the reference range of 10-55 ng/dL. They were randomized to receive transdermal testosterone or placebo twice weekly for 6 months.
As expected, treatment with the active product was associated with a significant increase (+37 ng/dL) in testosterone levels compared with placebo (-2 ng/dL). Moreover, use of the testosterone patch was well tolerated and did not adversely affect immune function, glucose and lipid metabolism, liver function, or body composition and did not promote hirsutism.
There was a trend toward increased muscle mass with testosterone therapy, the investigators point out. Moreover, subjects treated with the patch demonstrated significant improvements in shoulder flexion, elbow flexion, knee extension, and knee flexion compared with subjects who received placebo.
The results suggest that "testosterone may be a useful adjunctive therapy to maintain muscle function in symptomatic HIV-infected women," Dr. Grinspoon's group concludes.
Arch Intern Med 2004;164:897-904.


Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
  icon paper stack View Older Articles   Back to Top