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Ongoing Viral Replication in the Gut Despite HAART Suppressive Viral Control: Lack of Compartmentalization of HIV HIV-1 Quasispecies and Circulation of CXCR4 using HIV-1 between Gut Associated Lymphoid Tissue (GALT) and the Peripheral Blood (PB)
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Reported by Jules Levin
CROI Montreal Feb 8-12
Gerald Degray*1, R Dewar1, M Jiang1, P Mannon2, M Yao2, C Chairez2, I Sereti2, C Lane2, J Kovacs3, and H Imamichi1
1SAIC, Frederick, MD, US; 2NIAID, NIH, Bethesda, MD, US; and 3NIH, Bethesda, MD, US
AUTHOR CONCLUSIONS
The present study provided evidence of ongoing virus replication in the gut of HIV+ patients o prolonged suppressie HAART.
The similar distribution pattern of irus quasispecies between the gut and peripheral blood indicates fast equilibrium of HIV, thus free exchange of HIV-infected cells between these 2 compartments.
The simultaneous presence of X4 virus within the gut and peripheral blood further supports the notion.
INTRODUCTION
GALT contains a large number of activated CD4+CCR5+ T cells that are susceptible to HIV infection. Despite considerable interest generated in GALT as an important reservoir, our understanding of the contribution of GALT to active virus replication in the peripheral blood is limited. Our goal was to characterize HIV quasispecies in the gut and examine compartmental differences in HIV quasispecies between the gut and peripheral blood of HIV+ patients.
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