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Calcium & Heart Disease
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Effect of calcium supplements on risk of myocardial infarction and ...BMJ July 2010 - pdf attached
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Jul 29, 2010 ... One study reported a 24% increase in coronary heart disease in Finnish postmenopausal women using calcium supplements (with or without ...
www.natap.org/2010/newsUpdates/081110_05.htm
In this pooled analysis of around 12 000 participants from 11 randomised controlled trials, calcium supplements were associated with about a 30% increase in the incidence of myocardial infarction and smaller, non-significant, increases in the risk of stroke and mortality
"Prespecified subgroup analyses showed a significant interaction between treatment allocation and dietary calcium intake for myocardial infarction. Calcium treatment was associated with an increased risk of myocardial infarction in people with dietary calcium intake above the median of 805 mg/day (hazard ratio 1.85, 95% confidence interval 1.28 to 2.67) but no increased risk in those with dietary calcium intake below the median (0.98, 0.69 to 1.38, P for interaction 0.01). When the cohort was divided by fifths of dietary calcium intake rounded to the nearest 100 mg/day, the respective hazard ratios (95% confidence intervals) for the effect of calcium treatment on myocardial infarction were 1.18 (0.70 to 2.00) for <500 mg/day, 0.68 (0.39 to 1.18) for 500-699 mg/day, 2.28 (1.26 to 4.15) for 700-899 mg/day, 1.81 (0.97 to 3.41) for 900-1099 mg/day, and 1.41 (0.81 to 2.48) for ³1100 mg/day; test for linear trend when hazard ratios are expressed relative to the <500 mg/d fifth, P=0.12. Interactions between treatment allocation and age, sex, vitamin D status, or supplement type for myocardial infarction were not significant, nor were they between treatment allocation and any of these variables or dietary calcium intake for stroke, the composite end point, or death."
Calcium supplements boost heart-attack risk: Meta-analysis
Jul 29, 2010 ... Calcium supplements boost heart-attack risk: Meta-analysis ... The same holds true for cerebrovascular disease. There is something we need ...
www.natap.org/2010/newsUpdates/080610_21.htm
Until more becomes known about the best way to prevent osteoporotic fractures, the editorialists conclude that "patients with osteoporosis should generally not be treated with calcium supplements, either alone or with vitamin D, unless they are also receiving an effective treatment for osteoporosis for a recognized indication." They add that research on whether such supplements are needed in addition to effective osteoporosis treatment is "urgently required."
research into gender differences may yield answers to the increased risk of MI seen in this meta-analysis.
"In this analysis, 88% of the participants were women, and we know that cardiovascular disease in women is radically different from cardiovascular disease in men. The same holds true for cerebrovascular disease. There is something we need to get at, and at this point, no one has really been able to do so."
Schindler also said that the real risk of MI appeared to be in people who took calcium supplements on top of high levels of dietary calcium. "I think the safest thing to tell your patients right now is if you can get your dietary calcium from good dietary sources, such as yogurt, sardines, and skim milk, that potentially might be all you need to ward off the risk of osteoporosis. Then we don't have to deal with this increased cardiovascular risk."
He added that it is important to consider the potential safety concerns along with the benefits of bone health. "The benefits of calcium supplementation in older women with a low risk of fracture may not outweigh the potential cardiovascular risk."
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