icon-folder.gif   Conference Reports for NATAP  
 
  EASL 46th Annual Meeting
March 30th - April 3rd 2011
Berlin, Germany
Back grey_arrow_rt.gif
 
 
 
Evolution of Treatment-Emergent Variants in Telaprevir Phase 3 Clinical Trials
 
 
  Reported by Jules Levin
EASL 2011 Berlin Germany March 30-April 3
 
JC Sullivan, S De Meyer, DJ Bartels, I Dierynck, E Zhang, J Spanks, A Tigges, N Adda, EC Martin, IM Jacobson, KE Sherman, S Zeuzem, G Picchio, and TL Kieffer
 
from Jules: this presentation/data is based in part on a model predicting when & if mutations/resistance will disappear & not be very relevant or relevant at all. The general line here is that after 1.5 or more years resistance will not be relevant & you can retreat with the same protease because unlike in HIV the mutations do not integrate into the genome & aren't archived forever. The other minority view among resistance researchers I have worked with since 1996 do not accept this notion. At the very least their position is, and I agree, we don't know what will happen in patients several years from now after failing HCV protease inhibitor therapy, the worst potential scenario is if some patients will likely remain on failing regimens for prolonged periods of time while the recommendation will be to stop therapy very early if failure is observed and patients will be required to come in to check viral load after being on telaprevir for 4 and 12 weeks and with boceprevir likely 8 and 12 weeks. We will see.

EASL1.gif

EASL2.gif

EASL3.gif

EASL4.gif

EASL5.gif

EASL6.gif

EASL7.gif

EASL8.gif

EASL9.gif