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Gold nanoparticles to improve drug delivery to the CNS: Targeting HIV reservoirs in the brain (raltegravir)
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Reported by Jules Levin
IAC 2012 Wash DC July 22-27
C. Garrido1, N. Dahl1, CA. Simpson3, J. Bresee3, D. Feldheim3, C. Melander2 and DM. Margolis1
1UNC Chapel Hill, NC; 2NC State University, Raleigh, NC; 3University Boulder, Boulder, CO, USA.
The introduction of antiretroviral therapy (ART) has resulted in decreased incidence of HIV-associated dementia.
However, the entry of ART to the central nervous system (CNS) may be suboptimal due to the blood-brain-barrier (BBB), allowing the creation of a viral reservoir.
To improve the delivery of ART across the BBB, we have developed gold nanoparticles, which are inorganic crystals that can be covalently conjugated with hundreds of drug molecules.
In addition, these nanocrystals can be co-fabricated with targeting molecules, allowing the selective delivery to specific anatomic sanctuaries.
The aim of this study was to show that these nanoparticles enter into different cell types and exert antiretroviral activity upon conjugation with ARV drugs.
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