icon-    folder.gif   Conference Reports for NATAP  
  20th Conference on Retroviruses and
Opportunistic Infections
Atlanta, GA March 3 - 6, 2013
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A Longitudinal Study of the Effects of Ageing and HIV-1 Infection on Cognitive Performance
  Reported by Jules Levin
CROI 2013
B Haynes1, K Towgood1, S Casey2, J Dunn1, F Zelaya1, M Pitkanen1, R Kulasegaram3, G Barker1 & M Kopelman1 1King's College London, Institute of Psychiatry, London UK 2Aquired Brain Injury Ireland, Dublin Ireland 3Guys and St Thomas' NHS Foundation Trust, London UK


At baseline 20 younger (age 20-40) and 20 older (age 50-75) HIV-1 infected men were assessed on a broad cognitive test battery and compared to 20 younger and 22 older age and education matched controls. All patients were stable on HAART, with undetectable viral loads. The follow-up assessment, approximately four years after baseline, used the same test battery. Change scores were analysed using 2x2 analysis of variance, looking for a three way interaction between HIV status, age group and time. Results We report results from follow-up data on 53 individuals. There were significant (p<.05) interactions on global cognition and the visuo-spatial domain, and a trend (p<.10) on executive function. Follow-up investigation showed greater decline in the older HIV+ group than the HIV- older group, with no difference between the younger groups. Conclusions Despite no baseline differences, the present results hint towards greater cognitive decline in the older HIV+ group, which would support the notion of an interaction between HIV infection and ageing. This was most pronounced when the domains were combined into a global cognition measure. Results from the full sample at follow up will allow more definitive interpretations and correlations with imaging findings will be examined.