icon-    folder.gif   Conference Reports for NATAP  
  20th International AIDS Conference
July 20-25, 2014
Melbourne, Australia
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Monocyte activation markers remain significantly elevated in virologically suppressed HIV+ individuals to a level
equivalent to an additional 4 years of normal ageing

  Reported by Jules Levin
20th International AIDS Conference, July 20-25, 2014, Melbourne
Anna C. Hearps1,2* ,Thomas A. Angelovich1,3*, Anna Maisa1, Genevieve E. Martin1, Gregor F. Lichtfuss1,2, Wan-Jung Cheng1, Clovis S. Palmer1,4, Alan L Landay5, Suzanne M. Crowe1,3,6, Anthony Jaworowski1,2,7
1Centre for Biomedical Research, Burnet Institute, Melbourne, Australia, 2Department of Infectious Diseases, Monash University, Melbourne, Australia, 3School of Applied Sciences, RMIT University, Melbourne, Australia, 4School of Medical Sciences, University of New South Wales, Sydney, Australia, 5Rush University Medical Center, Chicago, IL, USA, 6Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia, 7Department of Immunology, Monash University, Melbourne, Australia. * Authors contributed equally.
"HIV infection increases monocyte activation by a level equivalent to up to 13 years of aging.....
.....This indicates viremic and VS HIV+ individuals have similar levels of activation biomarkers as uninfected controls aged up to 13 and 4 years older respectively........
.......Conclusion: HIV infection confers an increase in monocyte activation equivalent to up to 13 years of normal ageing in Viremic individuals and up to 4 years in VS individuals."