icon-    folder.gif   Conference Reports for NATAP  
  22nd Conference on Retroviruses and
Opportunistic Infections
Seattle Washington Feb 23 - 26, 2015
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Cerebral Vasoreactivity is Impaired in
Virally Suppressed HIV-infected Individuals
  Reported by Jules Levin
CROI Feb 23-26, Seattle, WA
Felicia C. Chow,1 Claire Mills,1 Nerissa U. Ko,1 Courtney Carroll,1 Richard W. Price,1 Steven G. Deeks,1 Farzaneh A. Sorond,2 Priscilla Y. Hsue1 1University of California San Francisco, San Francisco, CA, U.S.A., 2Brigham and Women's Hospital, Harvard University, Boston, MA, U.S.A.
"All HIV-infected participants were on a stable antiretroviral therapy (ART) regimen for at least 24 weeks with undetectable plasma HIV RNA level.......Cerebral vasoreactivity (VR), a measure of cerebrovascular endothelial function,7,8 is associated with small vessel and severe large artery cerebrovascular injury. .....The primary goal of the UNderstanding Cerebral VasoReactivity in HIV infection (UNCoVeR) study was to compare cerebral VR between treated, virally suppressed HIV-infected individuals and uninfected controls and to evaluate the effect of HIV-specific factors on cerebral VR."