icon-    folder.gif   Conference Reports for NATAP  
  Conference on Retroviruses
and Opportunistic Infections (CROI)
February 22-25, 2016, Boston MA
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Residual risk of disease progression after hepatitis C cure in HIV-HCV co-infected patients
  Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
D. Salmon1,2, C. Gilbert3, P. Sogni4,5, F. Dabis3,6,7, J. Bottero8, P. Miailhes9, L. Piroth10, F. Bani-Sadr11, L. Wittkop3,6,7 for the ANRS CO13 HEPAVIH 1Department of Internal Medicine and Infectious Diseases, Cochin Hospital, AP-HP, Paris, France. 2Paris Descartes University, Sorbonne Paris Cite, Paris, France. 3INSERM, ISPED, Centre INSERM U1219- Epidemiologie-Biostatistique, Bordeaux, France. 4Hepatology Unit, Cochin Hospital, AP-HP, Paris, France. 5Cochin Institute, INSERMU1016, Paris, France. 6CHU de Bordeaux, Pole de Sante Publique, Service d'Information Medicale, Bordeaux, France. 7Universite de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France. 8Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France. 9Department of Infectious and Tropical Diseases, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France. 10Department of Infectiology, CHU Dijon, Dijon, France. 11Department of Infectious Diseases, CHU Reims, Robert Debre Hospital, University of Champagne-Ardenne, Reims, France.


"Two patients developed an hepatic event (decompensated cirrhosis) after a median duration of 0.6 year after SVR (range: 0.2-1.0).....
For the two patients with an hepatic event, the last available Fibroscan value before the event was 10,3 and 27 kPa, 30 months and 6 months before the date of cirrhosis decompensation respectively.
Four deaths occurred, causes were bronchopneumonia in 1 (not linked to HCV neither HIV), and not yet validated by the independent committee for the three others. Median duration after SVR was 1.7 years (IQR: 0.6-3.8).
The respective last available elastometry in patients who died were 7.1, 16.5, 6.8 and 21.3 kPa, and were measured 30, 26, 26 and 23 months before death.
From Abstract: Causes of death were: cardio-vascular disease (n=1) and unknown (n=3)."