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DIFFERENTIAL REDUCTIONS IN VIRAL ANTIGENS EXPRESSED FROM CCCDNA VS INTEGRATED DNA IN TREATMENT NAÏVE HBEAG POSITIVE AND NEGATIVE PATIENTS WITH CHRONIC HBV AFTER RNA INTERFERENCE THERAPY WITH ARC-520
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Reported by Jules Levin
Curing HBV, New Drugs.....http://www.natap.org/2014/HBV/012215_01.htm
Curing HBV....attacking cccDNA "Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease"......http://www.natap.org/2014/AASLD/AASLD_151.htm............."..... in order to effectively clear an HBV infection and produce full remission, the viral cccDNA intermediates need to be destroyed
EASL 2016 April 14-17 Barcelona
Man-Fung Yuen* 1, Henry Lik Yuen Chan2, Kevin Liu1, Bruce D. Given3, Thomas Schluep3, James Hamilton3, Ching-Lung Lai1, Stephen A. Locarnini4, Johnson Y N Lau1, 5, Carlo Ferrari6, Robert G. Gish7, 8
1The University of Hong Kong, 2The Chinese University of Hong Kong, Hong Kong, China, 3Arrowhead Research Corporation, Pasadena, United States, 4Victorian Infectious Diseases Reference Laboratory, Victoria, Australia, 5Hong Kong Polytechnic University, Hong Kong, China, 6University of Parma, Parma, Italy, 7Stanford University, Palo Alto, 8Hepatitis B Foundation, Doylestown, United States
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