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Muscle mitochondrial function and
contemporary anti-retroviral therapy
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Reported by Jules Levin
9th International Workshop on HIV & Aging,
13th September 2018
Matthew Hunt
PhD student,
Wellcome Centre for Mitochondrial Research,
Newcastle University, UK
Mitochondrial Effects of HIV In ART-Naive
HIV infection is associated not only with mtDNA depletion, but also with extensive MRC disturbances and increased oxidative damage. HIV-infected patients had significant decreases in mtDNA content (decrease, 23%; P < .05) and in the activities of mitochondrial respiratory chain (MRC) complex II (decrease, 41%; P < .001), MRC complex III (decrease, 38%; P < .001), MRC complex IV (decrease, 19%; P = .001), and glycerol-3-phosphate dehydrogenase (decrease, 22%; P < .001), along with increased lipid peroxidation of PBMC membranes (P = .007).
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders
Overall, these data, along with the accompanying report, reveal a distinct alteration in mitochondrial morphology associated with HIV infection of the CNS and evidence that gp120 mediates these changes via altered mitochondrial fission/fusion and translocation along microtubules. The increase in mitochondria size is associated with severe HAND, and the alterations in fission/fusion machinery are observed early in neuronal models for HIV protein-mediated neurodegeneration. These data suggest that an imbalance in mitochondrial fission/fusion dynamics may be a compensatory mechanism that contributes to neurodegeneration in HAND patients.
LOWER MITOCHONDRIAL DNA COPY NUMBER IS ASSOCIATED WITH HIV & PREDICTIVE OF MORTALITY
Gait Speed/Mitochondria/ Functional Decline in HIV+ - The Role of Mitochondrial DNA Variation in Age-Related Decline in Gait Speed Among Older Men Living with HIV
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