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Hepatic Transcriptomic Analysis Identifies a Mast Cell Gene Expression Signature That
Correlates With Fibrosis Stage and Is Prognostic in Patients With Primary Sclerosing Cholangitis
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EASL 2020 Aug 27-29
Michael H. Trauner,1 Yevgeniy Gindin,2 Jing Zhu Zhou,2 Jun Xu,2 Xiaomin Lu,2 Andrew N. Billin,2 Chuhan Chung,2 G. Mani Subramanian,2 Robert P. Myers,2 Zachary Goodman,3 Andrew J. Muir,4 Douglas Thorburn,5 Christopher L. Bowlus,6 Cynthia Levy,7 Kris V. Kowdley8
1Medical University of Vienna, Austria; 2Gilead Sciences, Inc., Foster City, California, USA; 3Inova Fairfax Hospital, Falls Church, Virginia, USA; 4Duke Clinical Research Institute, Durham, North Carolina, USA; 5UCL Institute for Liver & Digestive Health, Royal Free Hospital, London, UK; 6University of California, Davis; 7University of Miami, Coral Gables, Florida, USA; 8Liver Institute Northwest, Seattle, Washington, USA
References: 1. Halilbasic E, et al. Dig Dis 2015;33:S149-63; 2. Muir AJ, et al. Hepatology 2019;69:684-98; 3. Jones H, et al. Hepatology 2016;64:1202-16; 4. Hargrove L, et al. Hepatology 2017;65:1991-2004; 5. Jarido V, et al. Am J Physiol Gastrointest
Liver Physiol 2017;313:G89-101; 6. Patro R, et al. Nat Methods 2017;14:417-9; 7. Lee E, et al. PLoS Comp Biol 2008;4:e1000217.
Acknowledgments: We extend our thanks to the patients and their families. This study was funded by Gilead Sciences, Inc.
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