%PDF-1.6
%
86 0 obj
<>
endobj
75 0 obj
<>
endobj
85 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
2021-01-08T03:46:09+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2021-02-06T07:24:17-08:00
2021-02-06T07:24:17-08:00
uuid:d654ad93-f640-4bf2-a062-c548ec1d302d
uuid:ede005e1-1dd1-11b2-0a00-5b00c8a9d9ff
application/pdf
Science Journals — AAAS
endstream
endobj
72 0 obj
<>
endobj
2 0 obj
<>
endobj
74 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 69 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 3 0 R/Type/Page>>
endobj
25 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 26 0 R/Type/Page>>
endobj
34 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 35 0 R/Type/Page>>
endobj
44 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 45 0 R/Type/Page>>
endobj
53 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 54 0 R/Type/Page>>
endobj
152 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
172 0 obj
[177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R]
endobj
173 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 622 Tm
(Senolysis by glutaminolysis inhibition ameliorates various age-associate\
d disorders)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 584.99991 Tm
(Furukawa, Seiya Imoto and Makoto Nakanishi)Tj
0 1 TD
(Nobuyuki Okahashi, Ryuta Mikawa, Makoto Suematsu, Makoto Arita, Masataka\
Sugimoto, Keiichi I. Nakayama, Yoichi)Tj
0 1.00001 TD
(Soichiro Kumamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Tomoyo Takami, R\
ui Yamaguchi, Eigo Shimizu, Kazutaka Ikeda, )Tj
0 1 TD
(Yoshikazu Johmura, Takehiro Yamanaka, Satotaka Omori, Teh-Wei Wang, Yuki\
Sugiura, Masaki Matsumoto, Narumi Suzuki,)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 538.99997 Tm
(DOI: 10.1126/science.abb5916)Tj
5.50301 1 Td
( \(6526\), 265-270.)Tj
/T1_0 1 Tf
-1.668 0 Td
(371)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 145.45605 442.99976 Tm
(, this issue p. 265; see also p. 234)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-3.125 1 Td
(therapeutic value of this approach.)Tj
0 1.00001 TD
(ameliorated aging-related organ dysfunction and obesity-related disorder\
s in mouse models, suggesting the potential)Tj
0 1 TD
(demonstrated that inhibition of this pathway induced the death of senesc\
ent cells. Glutaminase targeting also )Tj
0 1.00001 TD
(and Locasale\). The authors identified a key role for glutamine metaboli\
sm, particularly the enzyme glutaminase 1, and)Tj
0 1 TD
(used RNA interference to screen for enzymes essential to the survival of\
senescent cells \(see the Perspective by Pan )Tj
/T1_2 1 Tf
50.35892 1 Td
(et al.)Tj
/T1_1 1 Tf
-50.35892 0 Td
(potential targets for therapy, but we do not yet have a full understandi\
ng of the underlying mechanisms. Johmura )Tj
3.125 1.00001 Td
(Senescent cells are associated with a variety of age-related medical con\
ditions and thus have been proposed as)Tj
/T1_0 1 Tf
-3.125 1 Td
(Selective destruction of senescent cells)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 377 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 375 Tm
(http://science.sciencemag.org/content/371/6526/265)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 334.99997 Tm
(MATERIALS)Tj
0 1.00001 TD
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 339 Tm
(http://science.sciencemag.org/content/suppl/2021/01/13/371.6526.265.DC1)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 292.99997 Tm
(CONTENT)Tj
T*
(RELATED )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 264.99988 Tm
(http://stm.sciencemag.org/content/scitransmed/12/555/eaax8096.full)Tj
0 1 TD
(http://stm.sciencemag.org/content/scitransmed/12/566/eabd3816.full)Tj
0 1.00001 TD
(http://stm.sciencemag.org/content/scitransmed/13/575/eaba6110.full)Tj
0 1 TD
(http://stm.sciencemag.org/content/scitransmed/13/575/eabd2655.full)Tj
0 1.00001 TD
(http://science.sciencemag.org/content/sci/371/6526/234.full)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 249 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 238.99997 Tm
(http://science.sciencemag.org/content/371/6526/265#BIBL)Tj
0 g
0 1 TD
(This article cites 45 articles, 13 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 213 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 211 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
521 114 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
8 0 0 8 357.45605 93.99997 Tm
( is a registered trademark of AAAS.)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-32.125 0 Td
(Science, 1200 New York Avenue NW, Washington, DC 20005. The title )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 71.99997 Tm
(Science. No claim to original U.S. Government Works)Tj
T*
(Copyright \251 2021 The Authors, some rights reserved; exclusive license\
e American Association for the Advancement of)Tj
ET
BT
/T1_1 1 Tf
0 -8 8 0 575 326.42804 Tm
(on February 6, 2021)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
176 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(