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Subcutaneous Adipose Tissue Cell Composition is Associated with Visceral Fat Volume
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CROI 2023 Feb 20-23
Samuel S Bailin1, John J Carr1, Sangeeta Nair1, Heidi J Silver1, Mona Mashayekhi1, Curtis L Gabriel1, Rama D Gangula1, LaToya Hannah1,
Jonathan A Kropski1, Spyros Kalams1, Simon A Mallal1, John R Koethe1, Celestine N Wanjalla1
1Vanderbilt University Medical Center, Nashville, Tennessee, United States
Ectopic fat is defined by excess adipose tissue in locations not classically associated with adipose tissue storage. There are several potential mechanisms that might explain the tendency to deposit adipose tissue in ectopic versus nonectopic depots. One hypothesis suggests that, in states of positive energy balance, excess free fatty acids are initially stored subcutaneously, but once the capacity of SAT is reached, storage shifts to ectopic sites, including the viscera, heart, and vasculature.9,10 The most extreme manifestation of this results in lipodystrophy, characterized by a paucity of subcutaneous fat with resultant deposition ectopically. This failure of SAT to store additional free fatty acids is believed to result from a failure of proliferation and differentiation of adipocytes leading to subcutaneous adipose hypertrophy as opposed to hyperplasia.10,11
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