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Long COVID in people living with HIV
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may 2023 Current Opinion in HIV and AIDS


Purpose of review
It is now recognized that SARS-CoV-2 infection can have a long-term impact on health. This review summarizes the current state of knowledge regarding Long COVID in people living with HIV (PLWH).
Recent findings
PLWH may be at elevated risk of experiencing Long COVID. Although the mechanisms contributing to Long COVID are incompletely understood, there are several demographic and clinical factors that might make PLWH vulnerable to developing Long COVID.
PLWH should be aware that new or worsening symptoms following SARS-CoV-2 infection might represent Long COVID. HIV providers should be aware of this clinical entity and be mindful that their patients recovering from SARS-CoV-2 infection may be at higher risk. Based on these analyses, it remains possible and even likely, but not definitively proven, that HIV is a risk factor for Long COVID. Whether some of the excess risk for symptoms in PLWH can be attributed to factors such as smoking or comorbid conditions more frequent in this population requires studies with PLWH who do not have COVID-19 as a control group. Below, we outline the current research on the pathobiology of Long COVID and delineate why PLWH may be more susceptible to develop postacute symptoms and sequelae [54] (Fig. 1).

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