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A New Model of HIV Disease Progression
Based on the Accumulation of Non-AIDS Comorbidities
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IDWeek 2025 Oct 19-22 Atlanta
Senay Topala,b, Vincent C. Marconic,d,e, Joseph Lipscombf,g, Julia Gallinih, Nusrat Epsia,b, Kristopher Kuhnk,l, Xiuping Chua,b, Amy Justicei,j, Brian K. Agana,b
Comparison with other comorbidity measures
The measure is most similar to the Charlson Comorbidity Index (CCI), which considers a smaller set of diseases and applies different weights.
While CCI is one of the most widely used scoring system for comorbidities,[4] a systematic review and comparative analysis shows that among various comorbidities indices, Elixhauser index is a better predictor of the risk especially beyond 30 days of hospitalization.[5]
The Elixhauser comorbidity measure developed a list of 30 comorbidities relying on the ICD-9-CM coding manual. The comorbidities were not simplified as an index because each comorbidity affected outcomes (length of hospital stay, hospital changes, and mortality) differently among different patients groups. The comorbidities identified by the Elixhauser comorbidity measure are significantly associated with in-hospital mortality and include both acute and chronic conditions.
https://en.wikipedia.org/wiki/Elixhauser_Comorbidity_Index
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