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METFORMIN OVER TWO YEARS SHOWS NO EFFECT ON THE HIV RESERVOIR IN NON-DIABETIC PWH ON ART
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CROI 2026 Feb 22-25 Denver
Lucia Gutierrez-Garcia1, Andres Esteban-Cantos1,3, Cristina Marcelo-Calvo1,2,3, Rocio Montejano-Sanchez1,2,3, Javier Rodriguez-Centeno1, Rosa de Miguel2,
Patricia Martinez-Martin1,2,3, Alejandro De Gea Grela2, Jose I Bernardino2, Behzad Etemad4, Jonathan Z. Li4, Berta Rodes1,3, Jose R Arribas 1,2,3
1Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, 2Department of Internal Medicine, HIV Unit, La Paz University Hospital. Madrid, Spain. 3CIBER of Infectious Diseases (CIBERINFEC), Madrid, Spain 4 Brigham and women's hospital. Boston (MA), USA
In fact the study did find that the activity of the HIV reservoir (HIV RNA) did decrease over the study period in the metformin-treated group, it was just that HIV RNA in the placebo group also decreased over the same time frame so the differences between the two groups was not different in the end.
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