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High Baseline Prevalence and Suboptimal Control of Hypertension in the REPRIEVE Trial
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Hypertension is also one of the most significant predictors for many cerebrovascular diseases, particularly stroke.14, reported studies showed that among PLWH, elevated blood pressure was closely related to chronic kidney diseases and could aggravate renal dysfunction.17 HIV infection and treatment are themselves stressful and may significantly reduce the quality of life and well-being of PLWH,18 increasing the risk of developing hypertension. Having hypertension itself may add additional health burden. The success of antiretroviral therapy (ART) has substantially increased the survivorship of PLWH.2, 3 Along with rapid increases in life expectancy, PLWH face a new challenge: non-AIDS–related chronic diseases.4 Among various non-AIDS chronic diseases, hypertension is of particular significance.5 A number of influential factors may increase the risk of hypertension among PLWH. The proinflammatory effect induced by HIV infection on vascular endothelium may increase the risk of hypertension.6, 7 Receiving ART represents another risk factor for hypertension. Research has indicated that patients who received ART were more likely to have dysglycemia, hypertriglyceridemia, and lower levels of high-density lipoprotein cholesterol,8, 9 increasing the risk for hypertension. Furthermore, PLWH are more likely than the general population to be exposed to conventional risk factors for hypertension, such as tobacco use,10 stress,11 and kidney dysfunction.12 Recent data from one longitudinal study showed a rapid increase in hypertension incidence among PLWH.13
High Baseline Prevalence and Suboptimal Control of Hypertension in the REPRIEVE Trial
CROI 2026 Feb 22-25 Denver
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Risa Hoffman1, Maya Watanabe2, Esteban Martinez3,4, Anton Pozniak4,5, Saate S. Shakil6, Sara McCallum7, Sarah M. Chu7, Alex B. Lu7, Michael T. Lu8,
Judith S. Currier1, Markella V. Zanni7, Pamela S. Douglas9, Heather J. Ribaudo2, Steven K. Grinspoon7 for the REPRIEVE Study team
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