| |
Why Aging Accelerates at Age 50
|
| |
| |
Notably, tissues generally exhibit an increase in aging rate around 50 years, aligning with our established non-invasive multidimensional aging clocks.24,27
https://www.cell.com/cell/fulltext/S0092-8674(25)00749-4
Discussion
Human organ aging is a primary driver of numerous chronic diseases, yet the molecular mechanisms that govern its complexity and heterogeneity across organs remain largely elusive.11,106,107,108 Our study harnesses advanced quantitative proteomics to reveal the protein underpinnings of organ aging, creating a pioneering atlas across human tissues. This work offers innovative and in-depth perspectives for understanding, anticipating, and addressing aging with a protein-centric approach.
We introduce protein-based aging clocks and dynamic aging trajectories for human organs, illuminating their biological age and disease risks. Notably, tissues generally exhibit an increase in aging rate around 50 years, aligning with our established non-invasive multidimensional aging clocks.24,27 Our study highlights the early and pronounced aging of the aorta, underscoring the critical role of vascular senescence in initiating systemic aging through its extensive interactions with other organs and blood components. Integrating plasma and tissue data, we identified age-accumulating humoral senoproteins-pro-inflammatory senokines-that accelerate vascular and systemic decline. This reveals that blood vessels, as the primary senohub, are not only extremely aging-sensing units and reservoirs for receiving aging-related factors from peripheral tissues but are also significantly affected by organ aging itself.
|
|
| |
| |
|
|
|
