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Likelihood of Trying Long-Acting Injectable Antiretroviral Therapy Among Women With HIV in Nine Sites Across the United States
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McCrimmon, Tara MPH, MIAa; Collins, Lauren F. MD, MScb; Pereyra, Margaret DrPHa; Platamone, Corbin MPHc; Perez-Brumer, Amaya PhD, MScd; Shaffer, Victoria A. PhDe; Kerrigan, Deanna PhDf; Sheth, Anandi N. MD, MScb; Cohen, Mardge H. MDg; Hanna, David B. PhDh; Ramirez, Catalina MPH, CCRPi; Gange, Stephen J. PhDj; Rana, Aadia MDk; Tamraz, Bani PharmD, PhDl; Goparaju, Lakshmi PhDm; Wilson, Tracey E. PhDn; Alcaide, Maria MDo; Philbin, Morgan M. PhDp
JAIDS July 2024
Women in this study were recruited from 9 geographically diverse MWCCS sites: Atlanta, GA; Birmingham, AL/Jackson, MS; Bronx, NY; Brooklyn, NY; Washington DC; San Francisco, CA; Chicago, IL; Chapel Hill, NC; and Miami, FL. From October 2020 to September 2021, a computerized survey was administered to 1078 WLWH as part of data collection wave V101. None had participated in LAI ART clinical trials.
Nearly three-quarters (72%) had an undetectable viral load and 88% reported taking oral ART ≥95% of the time. Fewer than half of women (43%) reported they were “probably” (22%) or “definitely” (20%) likely to try LAI ART; 24.0% said that they definitely were not likely, 12.4% probably were not likely, and 21% were unsure.
In the adjusted model (Table 1), women reported being less likely to try LAI ART if they were older [adjusted odds ratio (aOR) = 0.98 per year (95% confidence interval: 0.96 to 0.99)] and reported taking oral ART ≥95% of the time [aOR = 0.67 (0.45 to 0.99)]. Women with past-year illicit substance use [aOR = 1.66 (1.07 to 2.56)] were more likely to try LAI ART, as were women from all other study sites compared with Miami, FL (aOR range: 2.04-4.51). There were no significant differences by race/ethnicity or educational attainment. Our findings did not change in a sensitivity analysis that used an ordinal logistic regression model with the uncategorized 5-point Likert scale.
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