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Sex-Specific Cardiometabolic Profiles and Severity of Liver Fibrosis
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In this nationally representative US cross-sectional study, we identified key differences in CMRFs that are associated with significant liver fibrosis among women vs men. Women with 2 or more CMRFs had markedly higher odds of significant fibrosis compared with women with fewer risk factors (aOR, 10.22 [95% CI, 4.76-21.95]), whereas the corresponding association in men had a more modest aOR (2.87 [95% CI, 1.91-4.31]).
Conclusions
In this cross-sectional study of US adults, we found that the presence of multiple CMRFs was associated with a greater increase in odds of significant liver fibrosis in women than in men; this was especially true of high WC and glucose intolerance. While these findings require confirmation in large prospective studies, this study highlights potential sex-specific differences that may inform future research on fibrosis risk assessment. Further work is needed to determine whether incorporating sex-specific considerations into metabolic risk evaluation or surveillance approaches is associated with improved early identification of advanced liver disease among women.53-55
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