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Oral Monthly PrEP MK-8527
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Merck Announces Initial Access Plans for Alimatravir, an Investigational Once-Monthly Oral HIV Pre-Exposure Prophylaxis in Phase 3 Development.....https://www.natap.org/2026/IAS/IAS_06.htm
Alimatravir Oral Once Monthly in Adults With Low Likelihood of HIV Exposure: A Randomized, Double-Blind, Placebo-Controlled Study - (09/22/26)
MK-8527 De Novo Resistance Selection in HIV-1 Subtypes A, B, and C and Prevalence of M184I/V Mutations in Persons Diagnosed With HIV Without a Known History of HIV Treatment
https://natap.org/2026/IAS/IAS_116.htm
MK-8527 Monthly PrEP Phase 3 Studies, In Lactating Women..... https://www.natap.org/2025/IAS/IAS_47.htm
CROI24: Discovery of MK-8527, a long-acting HIV nucleoside reverse transcriptase translocation inhibitor....... https://www.natap.org/2024/CROI/croi_07.htm
Single Dose Administration of MK-8527, a Novel nRTTI, in Adults With HIV-1 - (03/06/24)
Safety and Pharmacokinetics of MK-8527, a Novel nRTTI, in Adults Without HIV - (03/06/24)
MK-8527 Phase 3 Dose Selection for Monthly Oral HIV-1 Pre-exposure Prophylaxis...... https://www.natap.org/2026/CROI/croi_20.htm
Pharmacokinetics and Safety of MK-8527 in
Adults With Moderate or Severe Renal Impairment..... https://www.natap.org/2025/EACS/EACS_25.htm
Open-Label Phase 1 Study to Characterize the Effects of a Strong CYP3A4 Inducer on the Pharmacokinetics of MK-8527, a Nucleoside Reverse Transcriptase Translocation Inhibitor, in Adults Without HIV..... https://www.natap.org/2026/IAS/IAS_120.htm
MK-8527 PK/PD Threshold and Phase 2 Dose
Selection for Monthly Oral HIV-1 Preexposure Prophylaxis..... https://www.natap.org/2025/CROI/croi_10.htm
Open-Label Phase 1 Study of the Effects of Emtricitabine/Tenofovir Disoproxil Fumarate on the Pharmacokinetics of MK-8527, a Nucleoside Reverse Transcriptase Translocation Inhibitor, in Adults Without HIV.... https://www.natap.org/2026/IAS/IAS_118.htm
Phase 1, open-label study to evaluate the drug interaction between MK-8527, an HIV-1 nucleoside reverse transcriptase translocation inhibitor, and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females.... https://www.natap.org/2024/IAS/IAS_115.htm
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